[NEPHROLOGY] 9y/M PU,edema,Hx: URI

MCD
1 increased permeability of glom capi wall to plasma ptn > massive u. ptn (alb mostly)
2 decreased s. alb (cannot comp by liver synthesis) > colloid osm pr. > fluid to interstital space
3 depletion of intrav v. > reduced renal perfusion pr. > RAA >aldo // ADH secretion > water retention in collecting ducts
4 liver compensation ~synthesis of ptn&lipoptn ~ with decreased lipid catabol ~
5 lipiduria